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Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 69-79

Management strategies and critical appraisal of age-related macular degeneration (AMD): A systematic review

Central Ayurveda Research Institute (Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India), Bengaluru, India

Correspondence Address:
Dr. Bandahalli Madhusudhana Rao Bhavya
Central Ayurveda Research Institute (Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India), # 12, Uttarahalli Manavarthe Kaval, Uttarahalli (Hobli), Bangalore South (Tq.), Kanakapura Main Road, Talaghattapura Post, Bengaluru 560109.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jras.jras_66_21

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INTRODUCTION: Age-related macular degeneration (AMD) is a degenerative disease of macula associated with aging. It is the most leading cause of the central vision loss and blindness in the developed countries above the age of 55 years. OBJECTIVES: The aim of this article is to critically analyze and to provide quality evidence in view of safety, efficacy, and effectiveness of Ayurveda interventions. MATERIALS AND METHODOLOGY: The study reviewed randomized controlled trials (RCTs), non-RCTs, and case studies on the management of AMD in Ayurveda. They were retrieved through Ayurveda research databases and Medical Journal databases such as MEDLINE, SCOPUS, Web of Science, and other directories of open access journals. Hand searching was done using predefined search terms. The search was limited to articles published till July 2021. Study selection followed the symptomatology of AMD. The data were documented and extracted using study ID and design, sample size, duration, interventions, outcomes, and result. The quality and the risk of bias assessment were done using available tools. Quantitative synthesis was not attempted as we aimed at only systematic review. RESULTS: There were 28 screened records of which 6 fulfilled pre-defined criteria. Most commonly adopted therapeutics include four studies on Nasya (medication through nose), five on Tarpana (lubrication of eye), and two studies focussing on Basti (therapeutic enema) as primary management. The results were categorized under Shodhana (purification therapy) and Shamana (palliative). Overall studies show a significant improvement in subjective parameters assessed through gradation index. Panchakarma combined with eye treatment showed better relief. CONCLUSION: The study outcome yielded considerable improvement in vision and also assisted in maintaining existing vision which is greatly appreciable in addressing the subject’s quality of life by controlling further progression of the disease.

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