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 Table of Contents  
Year : 2021  |  Volume : 5  |  Issue : 4  |  Page : 185-191

Management of moderate cases of COVID-19 through treatment protocol of Ministry of AYUSH: A case series

1 All India Institute of Ayurveda, New Delhi, India
2 Vikriti Vigyan, IMS, BHU, Varanasi, Uttar Pradesh, India

Date of Submission26-Jul-2021
Date of Decision12-Feb-2022
Date of Acceptance15-Feb-2022
Date of Web Publication29-Apr-2022

Correspondence Address:
Shalini Rai
All India Institute of Ayurveda, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jras.jras_23_21

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The global resurgence of coronavirus 2 (SARS-CoV-2) has severely affected the medical infrastructure, posing a serious public health concern. The present case series documents the successful management of four moderate cases of confirmed coronavirus disease (COVID-19) based on the Ayurveda approach without any adverse effects and any post-COVID presentation. A retrospective analysis of four patients with moderate COVID-19 symptoms was conducted in this study at the All India Institute of Ayurveda. The patients were between the age of 23 and 38 years, were diagnosed as COVID-19 positive through a rapid antigen test (RAT), in July–August 2020, and were managed through Ayurveda interventions. The interventions include Ayush Kwath (10 g twice a day) and Sanshamani Vati (500 mg thrice a day) along with dietary restrictions and nonpharmacological suggestions. The therapeutic interventions were carried out for 7 days. Symptomatic assessment was done every day telephonically, and RAT was conducted after 7 days. Post-COVID complications were assessed in individual cases during the follow-up period (3 months after the completion of treatment). Complete relief in symptoms was observed within 6–7 days in all the cases. No side effects or adverse drug reactions were noticed both during and after the treatment. No post-COVID complications were observed in the four studied cases. The case series suggests that timely Ayurveda intervention has very good potential not only in treating mild-to-moderate patients of COVID-19 infection but also in preventing the post-COVID complications. It could also have a role in reducing the burden of a patient’s turning into a severe category or with complications. However, large-scale randomized controlled trials are required to further validate the same.

Keywords: Ayush Kwath, COVID-19, infection, moderate, rasayana, Sanshamani vati

How to cite this article:
Sharma M, Mandal SK, Raahat S, Pawar AS, Rai S, More A, Nesari T. Management of moderate cases of COVID-19 through treatment protocol of Ministry of AYUSH: A case series. J Res Ayurvedic Sci 2021;5:185-91

How to cite this URL:
Sharma M, Mandal SK, Raahat S, Pawar AS, Rai S, More A, Nesari T. Management of moderate cases of COVID-19 through treatment protocol of Ministry of AYUSH: A case series. J Res Ayurvedic Sci [serial online] 2021 [cited 2022 Nov 26];5:185-91. Available from: http://www.jrasccras.com/text.asp?2021/5/4/185/344408

  Background Top

Coronavirus disease (COVID-19) has become a global challenge that has demanded researchers, policy makers, and the government to address multiple dimensions to contain such a pandemic. Since, COVID-19 requires a structured approach covering preventive (exposed), curative (early and advanced stages of the confirmed case), and hospitalization (critical patients) care, the role of traditional Ayurveda medicines having immunomodulatory and adeptogenic effects is gaining momentum.[1] On the basis of the traditional Chinese medicine (TCM) treatment used very effectively to treat COVID-19 infections, a reduction in the overall duration of treatment, shortening of the clinical recovery period improvement rate of CT image and clinical cure, a reduction in the rate of conversion of mild-to-moderate symptoms into severe disease, a reduction in the time of polymerase chain reaction test turning negative, and a reduction in the average length of stay in hospital by more than 2 days in the severe cases were reported.[2],[3] A good number of trials are registered for evaluating the efficacy of Ayurveda interventions in the prevention and management of COVID-19, out of which 107 studies (as on August 20, 2020) are based on the guidelines issued by the Ministry of Ayush.[4]

This case series presents the report of four moderate uncomplicated patients between the age of 23 and 38 years, diagnosed with COVID-19 through the Rapid antigen detection test (RADT). The disease corresponds to Kapha-Vata dominant Sannipatika Jvara in classics and was treated on the line of Jvara Chikitsa, with Ayurvedic interventions having antipyretic, anti-inflammatory, and immunomodulatory actions.

  Case Description Top

Four cases having mild to moderate symptoms of COVID-19 and confirmed positive through RAT were treated with Ayurveda interventions at an outpatient/inpatient department (OPD/IPD) facility of the All India Institute of Ayurveda (AIIA) from July to August 2020 [Figure 1]. General and clinical examinations of observed cases are depicted in [Table 1] & [Table 2]. The summarized case information of the four cases is given next.
Figure 1: RADT before treatment

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Table 1: Showing the Dashvidha pareeksha (tenfold examination)

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Table 2: Showing the general examination

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Case 1

A 26-year-old male, a computer operator, a resident of Panchwati Exn. Ghaziabad (U.P.), reported to the COVID testing centre (CTC) at AIIA. He was suffering from fever, sore throat, tiredness, and body ache for the past two days. No contact history (with a COVID-positive patient) could be traced. No comorbidities/surgeries/drug allergy or addictions were reported.

Case 2

A 35-year-old male dry cleaner, a resident of Gautampuri, Delhi, visited CTC, AIIA, with complaints such as body ache, fatigue, and loss of appetite for the past two days. There was contact history with a diagnosed COVID-19 positive patient. There was no history of previous surgeries/drug allergy/any chronic illness or addiction.

Case 3

A 23-year-old female graduate student, from Jasola Vihar, Delhi, reported to CTC, AIIA, with chief complaints of fever, body ache, cough, and complete loss of taste and smell for the past two days. History of contact with COVID-positive cases could not be traced. Her past history suggested no major illness/surgery or drug allergy.

Case 4

A 38-year-old housewife residing in Banadana Enclave, Ghaziabad, reported to Flu OPD, AIIA, with complaints of fever, headache, fatigue, body ache, and anorexia for the past two days. Her past history did not reveal any major surgery, illness, or drug allergy.


RADT confirmed the diagnosis of COVID-19 in all the four cases. From the Ayurvedic point of view, based on the manifested symptoms, the cases were diagnosed as Vata-Kapha dominant Sannipatika Jvara.[5] The stage of Jwara was Amavastha as there were symptoms such as anorexia, loss of taste, heaviness of body parts, fatigue, drowsiness etc and the duration of fever was less than eight days.

  Intervention Timeline and Clinical Assessment Top

Ayush Kwath in the dosage of 20–30 ml twice a day in the lukewarm state, half an hour before a meal, and Sanshamani Vati 500 mg thrice a day, after a meal with lukewarm water, were prescribed for seven days. The patients were kept in isolation at their home. Along with medication, the patients were also advised to take bed rest, adequate sleep, plenty of warm fluids, light, easily digestible food items (porridge, Yusha, Krishra, fruits); perform gargling with lukewarm water containing Saindhava Lavana (rock salt) thrice a day and drinking of Haridra [(Curcuma longa L.)] added milk [200 ml hot milk with 3 gm Turmeric powder]. Nonpharmacological interventions like Yogasana, such as Sukhasana, Vajrasana along with Kapalbhati and Bhramari Pranyama, were advised to the patients for a short duration based on their capacity to perform exercise. They were also advised to maintain their positive state of mind. Daily consultation was done through telephonic communication. Assessment of clinical improvement was done as per the established criteria for fever, headache, bodyache, cough, anorexia, fatigue, and sore throat[6],[7],[8],[9],[10],[11] [Table 3].
Table 3: Assessment criteria for symptoms

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Follow-up period

After seven days of treatment, the post-treatment follow-up to observe for any post-COVID complications was done at the 30th day.

  Outcome Top

Significant relief in such as fever, cough, and anorexia was observed in all cases within the first two days. The cases also showed marked improvement in headache, body ache, and sore throat. Within four days of medication, the majority of the symptoms had subsided totally. On day 6, case 4 achieved smell and taste perception. By the 10th day, fatigue in cases 1 and 4 had subsided [Table 4]. No post-COVID symptoms and any adverse events were reported in any of the cases. All cases were advised to repeat RADT after six days or after turning asymptomatic, whichever was earlier, and were recorded as COVID-19 negative [Figure 2].
Table 4: Daily assessment of symptoms (n = 4)

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Figure 2: RADT after treatment

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  Discussion Top

In classical texts of Ayurveda, health, disease, and pathogenesis, clinical outcomes and management protocols of epidemics are described that can aid in the management of epidemic situations up to a certain extent.[12] According to the classical concept of Ayurveda, if a disease is not found mentioned in literature, then the treatment plan can be made on the basis of determination of etiopathogenesis, the involved body system, the affected organ, attributes of vitiated Dosha, and manifested clinical symptoms. Based on this classical concept, the pathogenesis of studied cases can be decided as Kapha-Vata dominant Tridoshas, which affected the nutrient circulatory body fluid (Rasa Dhatu) along with blood (Rakta Dhatu) as well as the respiratory system (Pranavaha Srotasa) and manifested with the clinical features of fever, body ache, anorexia, loss of taste, fatigue etc. As per the prognostic criteria of Ayurveda, the cases may be included easily in the curable category due to the mild to moderate presentation of the disease symptomatology, moderate Dhatu Samhanan, Prakriti of the patients not being congruent to the Doshas of the disease, and good resilience of the patients.

Considering the components of pathogenesis, the management principle of Amavastha Jvara was adopted, which included the stimulation of digestion (Agnideepana and Amapachana), purification of circulatory channels (Srotosodhana), and pacifying Kapha-Vata. The four drugs in Ayush Kwath, by virtue of the digestive stimulant, channel the purification property along with immunomodulatory actions and may have certain pharmacological action in resolving the pathogenesis in mild to moderate cases of COVID-19[13],[14] [Table 5]. Ocimmum sanctum has antimicrobial, antiviral, antidiarrheal, antimalarial, antioxidant, antipyretic, and immunomodulatory potential.[15],[16],[17],[18]C. zeylanicum has immunomodulatory,[19] antimicrobial, antimicrobial[20] A2 receptor antagonist, anticoagulative, and anti-atherosclerotic action,[21] which can help in boosting the immune system and prevent the coagulopathies associated with COVID-19. A study in mice demonstrated an increase in humoral and cell-mediated immune responses after the administration of crude and alcoholic extracts of Z. Officinales.[22] Gingerols and shogaols component extracted from the rhizome of ginger are proven to possess anti-inflammatory, antioxidative, and antiaggregant potential.[23] Evidence from various experimental and cell line studies confirms the immunomodulatory, antioxidant, analgesic, antiplatelets, antiasthmatic, antipyretic, anti-inflammatory, antidiarrheal, antidepressants, hepatoprotective, antiulcer, antiapoptotic, antimetastatic, antimutagenic, antibacterial, antifungal, and antiamoebic properties of P. nigrum.[24],[25],[26],[27]Sanshamni Vati has Guduchi (Tinospora Cordifolia [Willd.] Hook.f. and Thomas) as the main content. Studies have revealed the immunomodulatory,[28] analgesic, anti-inflammatory, antipyretic,[29] and adeptogenic action of T Cordifolia.[30]In silico studies have also shown the high binding efficacy of T Cordifolia against SARS-CoV-2 targets engaged for viral attachment and replication, as evaluated in Remdesivir, Favipiravir, and Lopinavir/Ritonavir.[31] These evidences of the action of herbal ingredients of Ayush Kwath and Sanshamani Vati are supportive of the intended action and observed results in the studied COVID-19 cases. The interventions of Ayush Kwath and Sanshamani Vati along with the holistic care approach implemented simultaneously using a conducive diet and behaviors have shown the potential role in reversing the pathology in mild to moderate stages of COVID-19. Though milk is contraindicated in fever as per the classics, yet here milk containing Turmeric (C. longa) was prescribed due to the antioxidant, analgesic, antibacterial, and antiviral action of C. longa.[32],[33] Milk was advised as it has nutrient, rejuvenating, enlivening, and nourishing effects and it improves the immunity of the body, which is expected while treating an illness such as COVID-19.
Table 5: Contents and pharmacological action of Ayush Kwath

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In all studied cases, the major symptoms were relieved within five days of the commencement of medication and complete recovery was seen within 10 days. There were no post-COVID complications observed during the study period, which indicates the potential role and efficacy of the Guidelines of Ministry of Ayushin while curing the pathogenesis of mild to moderate cases of COVID-19. The results of other trials based on the Guidelines of Ministry of Ayush are yet awaited in the public domain, but this case report provides some proof to the efficacy of the interventions such as TCM. Though at this juncture, no certain conclusions can be drawn, yet younger age, coupled with no comorbidity and hypoxemia, could also have been the contributing factors for early recovery with the Ayurveda intervention.

  Conclusion Top

Ayurveda intervention (Ayush Kwath and Samshani Vati) has good clinical efficacy in mild to moderate cases of COVID-19. The intervention can relieve symptoms within 5–10 days and may also help in nullifying the possibility of post-COVID complications. However, further clinical studies on a larger sample size are required to validate the findings of this case series.

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Conflicts of interest

There are no conflicts of interest.

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  [Figure 1], [Figure 2]

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]


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